Progestins VS Progesterone
Synthetic progestins are molecularly different from natural progesterone and therefore do not metabolite to the same compounds as natural progesterone. They do not show benefits for cognitive or anti-anxiety function. In fact, they have not been found to have any of progesterone's neuroprotective properties. The progestin that has been the most extensively studies and which is commonly used in synthetic hormone replacement therapy, MPA (medroxyprogesterone acetate), has been found to have negative effects on the nervous system and even reduces the beneficial effects of estrogen.
@Women in Balance Institute